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Primary and Secondary Endpoints The primary endpoints for TRIUMPH-1 follow the standard FDA framework for obesity drug approval

The STEP 5 trial confirmed that at 2 years, weight loss stabilized at -15.2% from baseline meaning the body reaches a new set point where caloric intake and expenditure balance out (Garvey et al., 2022)

The Wegovy pill, taken once a day, works similarly to the weekly injectionsmimicking the activity of a gut hormone that slows down the speed at which peoples stomach empties and that makes them feel fuller

In a similar manner, products which serve the sole purpose of helping you to lose weight dont really have a big place in this new paradigm, so a company like MediFast (MED) or Herbalife (HLF) could have issues